Editor’s Note: Competition in major science and technology missions is increasingly becoming a comprehensive contest of technological, industrial, and organizational capabilities. In 2026, the White House released “Science: A New Golden Age”, identifying reforms to the organization of scientific research and funding mechanisms as important issues in federal science and technology policy; the Third Plenary Session of the 20th Central Committee of the Communist Party of China likewise called for efforts to “optimize the organizational mechanisms for major scientific and technology innovation.” However, existing science and technology intelligence work tends to focus more on technology pathways, innovation entities, and industry dynamics, while paying insufficient attention to organizational issues such as who should undertake a mission, how responsibilities should be divided, what organizational instruments should be employed, and when mechanisms should be adjusted. Against this backdrop, this journal invited the author to examine NASA’s commercial space programs as a case study, analyze the underlying logic of the selection and transition of their organizational mechanisms, and, on this basis, propose an intelligence support framework for decision-making on the organizational mechanisms of China’s major science and technology missions. This article aims to broaden the boundaies of intelligence analysis for major science and technology missions, extend the focus beyond technology and industry themselves to organizational dimensions such as mission conditions, the allocation of rights and responsibilities, competition structures, and mechanism transitions, and to carry this analysis throughout the entire process of mission appraisal, organization implementation, and dynamic adjustment, thereby providing more targeted intelligence support for the design, selection, course correction, and with drawal of organizational mechanisms for major science and technology missions.